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KMID : 0378019720150110077
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New Medical Journal
1972 Volume.15 No. 11 p.77 ~ p.80
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Immune Response of Survived Mice following Active Immunization against Subaxillary Implanted Tumor
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Abstract
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It is a well known fact that immunotherapy of tumor consists of active immunization, passive immunization, adoptive immunization and treatment with immunogeneic nucleic acids. It has now been firmly established that active immunization of a susceptible animal with live tumor cells given in subliminal dose, with properly killed tumor cells, or with the oncogenic virus establishes immunity and solid resistance to challenge with either the oncogenic virus or with tumor cells.
Cho and Kim (1972) observed a high level of immunity was produced in mice against subcutaneously implanted sarcoma 180 by mounting of diffusion chamber containing live tumor cells and suggested the immunity produced by live tumor cell was cell-mediated. It is also a well known fact that in the cellmediated immune reaction a small thymus-dependent lymphocyte transforms into a large pyroninophilic cell at the thymus-dependent area-paracortical area of the lymph node and periarterial sheath of the spleen, in response to antigen, which will elicit either a delayed hypersensitivity reaction or an allograft rejection response (Parrott et al., 1966).
In this paper we made an attempt to observe the response of thymus-dependent area both of the spleen and the mesenteric lymph node of the survived mice against subcutaneously challenged tumor following active immunization with live sarcoma 180 ascites tumor cell in intraperitoneally mounted diffusion chamber.
The results were as follows:
Proliferation of large lymphoid cells in periarterial sheath of the spleen and paracortical area of the mesenteric lymph node was prominent in the survived mice 60 days after subaxillar challenge of sarcoma 180 ascites tumor, which is inoculated 3, 4 or 5 weeks after mounting, or 2 weeks after removal of mounted diffusion chamber for 3 week duration.
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